ABSTRACT
INTRODUCTION: Trying to increase the specificity and demonstrated sensibility of thyroid fine needle aspiration (TFNA) in the diagnosis of the thyroid nodule, and to improve the cytomorphologic diagnosis, we used the approach of realization of thin prep (TP), adapting the technique to the methods within our possibilities. MATERIALS AND METHODS: The sample corresponded to a prospective study of 200 cases of material of thyroid nodules, obtained by means of ultrasonography guide fine needle aspiration, over a 30 month period. The study was carried out by means of conventional smear (CS) and TP, cytologic preparations were stained with hematoxilin-eosine (H-E), Papanicolaou (PAP) and Tint 15. The analysis of these same samples was carried out according to sex, age, characteristics of the nodules and cytomorphologic features. RESULTS: The samples were satisfactory in 184 cases (92 per cent) and unsatisfactory in 16 cases (8 per cent). The prevalence in samples corresponded to the female sex (88.5 per cent). The pre-emptive diagnoses corresponded to: Multinodular Goiter: 41 (22.29 per cent)--Hashimoto's thyroiditis: 4 (2.17 per cent)--Follicular lesions I: 86(46.74 per cent), II: 34 (18.47 per cent), III: 6 (3.26 per cent)--Hurthle cell neoplasm: 4 (2.17 per cent)--Papillary carcinoma: 9 (4.90 per cent). The patient study was carried out according to the modified algorithm proposed by Gharib in 1997 and the Department of Cytology of the Karolinska Hospital of Stockholm (Sweden). The cytological diagnosis was compared to the final histological results. CONCLUSIONS: The present work has demonstrated that even with the available methods, we have been able to carry out TP that were acceptable for its evaluation and with the same limitations of those obtained by CS, with respect to preparations dried in direct air and in the cases of non-conclusive diagnoses. We obtained a sensibility of 94.44 per cent and a specificity of 98.79 per cent.
Subject(s)
Adolescent , Humans , Male , Female , Adult , Middle Aged , Biopsy, Needle/methods , Histocytological Preparation Techniques/methods , Thyroid Nodule/pathology , Follow-Up Studies , Predictive Value of Tests , Prospective Studies , Sensitivity and SpecificityABSTRACT
La punción aspiración con aguja fina (PAAF) de tiroides ha demostrado ser altamente sensible y específica para establecer un diagnóstico e implementar el tratamiento correspondiente. Dichas cualidades están incrementadas cuando se utiliza la guía ecográfica: Punción aspiración ecoguiada con aguja fina de tiroides (PAEAFT). Presentamos 139 casos de PAEAFT estudiados mediante extendidos convencionales y delgados según técnica específica, coloreados con hematoxilina-eosina - Tinción 15 (DIFF-QUIK) y Papanicolaou; analizamos su distribución por sexo, edad, topografía, características de el/los nódulos y diagnóstico citológico. Los diagnósticos presuntivos correspondieron a: Bocio multinodular (21.58 por ciento) - Tiroiditis de Hashimoto (2.87 por ciento) - Lesiones foliculares: Bajo grado (I-II): (57.57 por ciento), Alto grado (III): 2.15 por ciento - Tumor de células de Hürthle (2.87 por ciento) - Carcinoma Papilar (4.32 por ciento). La prevalencia correspondió al sexo femenino (93.52 por ciento). El seguimiento de los pacientes se realizó en base al algoritmo propuesto por Gharib, modificado. (11).